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ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity

Experimental studies show a substantial contribution of early life environment to obesity risk through epigenetic processes.

Strongyloides seroprevalence before and after an ivermectin mass drug administration in a remote Australian Aboriginal community

We report the impact on Strongyloides seroprevalence after two oral ivermectin mass drug administrations (MDAs) delivered 12 months apart in a remote Australian Aboriginal community.

Maternal alcohol disorders and school achievement: a population cohort record linkage study in Western Australia

Children of mothers with alcohol use disorders are at risk of not meeting minimum educational benchmarks in numeracy and literacy, with the risk highest among Indigenous children.

The impact of child maltreatment on the risk of deliberate self-harm among adolescents: A population-wide cohort study using linked administrative records

This study calls for the early identification of children who are vulnerable to maltreatment, the better identification of the duration and severity of maltreatment experiences, and the provision of continued care and support, to reduce the child's deliberate self harm risk in adolescence.

Adherence to secondary prophylaxis for rheumatic heart disease is underestimated by register data.

Adequate resources are needed for maintenance of data quality in acute rheumatic fever/ rheumatic heart disease registers to ensure provision of evidence-based care and accurate assessment of program impact.

Creating community indicators for early childhood development: challenges and innovations from the kids in communities study

The community (or neighbourhood) is seen as a potential point of intervention for improving early childhood development outcomes through place-based approaches targeting all children. Yet there are insufficient robust data to guide policy and practice. Developing community factors for early childhood development is one way to facilitate more informed, evidence-based community action. This paper discusses the methodological learnings from the Kids in Communities Study, an Australian investigation into community-level factors important for early childhood development, including some of the challenges and innovations associated with the measurement and development of indicators.

Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity

There has been a coordinated effort from academic institutions and the PI to identify biomarkers that can predict immune checkpoint blockade response in cancer.

Population-based estimates of the effectiveness of pneumococcal vaccination in Australia

Australia’s Childhood Immunisation Register (ACIR) is one of only a handful of national immunisation registers world-wide.

Caesarean section and risk of autism across gestational age: a multi-national cohort study of 5 million births

The positive association between caesarean section (CS) and autism spectrum disorder (ASD) may be attributed to preterm delivery.