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The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simultaneously investigate the effects of multiple intervention modalities within multiple groups of participants with different forms of S. aureus bloodstream infection.
Neisseria meningitidis is commensal of the human pharynx and occasionally invades the host, causing the life-threatening illness invasive meningococcal disease. The meningococcus is a highly diverse and adaptable organism thanks to natural competence, a propensity for recombination, and a highly repetitive genome.
Varicella (chickenpox) is an infectious disease caused by the varicella zoster virus affecting children, adolescents, and adults. Varicella symptoms are usually self-limiting; however, different complications with widespread and systemic manifestations can occur. This systematic literature review aims to explore and quantify varicella-associated complication rates.
There is low coverage of the multivalent M protein vaccine in our setting, emphasizing the need to reformulate the vaccine to improve coverage
Non-Aspergillus molds and non-albicans Candida contributed substantially to pediatric invasive fungal infection in our study
We write this perspective to raise awareness of antimicrobial resistance as an issue in Indigenous primary health care
Health care-associated bacteraemia has a significant impact on child health, exceeding the number of community-acquired bacteraemia at our hospital
Efforts to eliminate ARF and RHD in Australia over the past decade have so far been unsuccessful, but this can change
Scabies causes considerable morbidity and leads to severe bacterial infection and immune-mediated disease
Aboriginal children are at greater risk of rotavirus disease than non-Aboriginal children and delayed vaccine receipt is substantially higher