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Research
A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding studyStreptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines. We describe the initial Controlled Human Infection for Vaccination Against S pyogenes (CHIVAS-M75) study, in which we aimed to identify a dose of emm75 S pyogenes that causes acute pharyngitis in at least 60% of volunteers when applied to the pharynx by swab.
Research
A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.This publication is a systematic analysis of all Group A Streptococcus M protein variants, to assist in the development of a vaccine.
Research
High Nasopharyngeal Carriage of Non-Vaccine Serotypes in Western Australian Aboriginal People Following 10 Years of Pneumococcal Conjugate VaccinationInvasive pneumococcal disease (IPD) continues to occur at high rates among Australian Aboriginal people.
Research
A randomized, controlled, phase 1/2 trial of a neisseria meningitidis serogroup B bivalent rLP2086 vaccine in healthy children and adolescentsFactor H binding protein (also known as LP2086) is a conserved outer membrane neisserial lipoprotein that has emerged as a strong candidate protein antigen...
Research
Immunization of newborns with bacterial conjugate vaccinesBacterial conjugate vaccines are based on the principle of coupling immunogenic bacterial capsular polysaccharides to a carrier protein to facilitate the...
Research
Invasive group A streptococcal infection in the Northern Territory, Australia: Case report and review of the literatureThis review article presents the case of infant Aboriginal twins with invasive group A streptococcal infection complicated by streptococcal toxic shock...
Research
Comparison of three methods for the recovery of skin pathogens from impetigo swabs collected in a remote community of Northern Territory, AustraliaImmediate plating of impetigo swabs is the gold standard for bacterial recovery but is rarely feasible in remote regions.
News & Events
National honour for infectious diseases researcherPerth researcher dedicated to reducing serious chest and ear infections in children has been recognised with the award of Officer in the Order of Australia
News & Events
Trial begins of first vaccine against Ross River VirusPerth researchers are seeking volunteers to test the effectiveness of a vaccine against the debilitating Ross River Virus.
News & Events
New vaccine promises fewer needlesPerth researchers are calling for help from Perth toddlers and their parents to participate in a new project that aims to reduce the number of injections