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Research

Preterm infants are at a high risk of developing late-onset sepsis (LOS). Lactoferrin is one of the most abundant endogenous antimicrobial proteins expressed in breast milk, stools, and blood, and a candidate for preventive intervention. Large clinical trials have recently investigated whether enteral supplementation with bovine lactoferrin reduces LOS.

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Despite the existence of a national alcohol guideline for breastfeeding women, maternal health practitioners are not incorporating this advice

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School-based social risk processes in the lives of young people with chronic health conditions are likely to contribute to risk of psychological problems

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The findings indicated that in spite of continued promotion of the AIFG over the past ten years achieving the around six months guideline is challenging

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IL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition

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We must celebrate success and hope through a process of mapping and building recovery capital in the justice context at an individual and institutional level

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Improving maternal gut health in pregnancy and lactation is a potential strategy to improve immune and metabolic health in offspring and curtail the rising rates of inflammatory diseases linked to alterations in gut microbiota. Here, we investigate the effects of a maternal prebiotic supplement (galacto-oligosaccharides and fructo-oligosaccharides), ingested daily from <21 weeks' gestation to six months' post-partum, in a double-blinded, randomised placebo-controlled trial. 

Research

Mild traumatic brain injury (mTBI) is a complex injury with heterogeneous physical, cognitive, emotional and functional outcomes. Many who sustain mTBI recover within 2 weeks of injury; however, approximately 10%-20% of individuals experience mTBI symptoms beyond this 'typical' recovery timeframe, known as persistent post-concussion symptoms (PPCS). Despite increasing interest in PPCS, uncertainty remains regarding its prevalence in community-based populations and the extent to which poor recovery may be identified using early predictive markers.

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Cow's milk allergy is rare in exclusively breastfed infants. To support the continuation of breastfeeding an infant after diagnosis with a cow's milk allergy, it is critical to examine the evidence for and against any form of cow's milk elimination diet for lactating mothers. In this narrative review, we highlight the lack of high-quality evidence, hence subsequent controversy, regarding whether the minuscule quantities of cow's milk proteins detectable in human milk cause infant cow's milk allergy symptoms.

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These findings suggest that genetic variants at the VDR locus may play a role in acute wheeze/asthma severity in children

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Our work has identified a clinically relevant host-derived factor that may participate in shaping early events in the aetiology of CF respiratory disease

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We investigated immune and non-immune related genes to determine other factors required for the development of Abacavir hypersensitivity syndrome

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Itraconazole remains a first-line antifungal agent for certain fungal infections in children, including allergic bronchopulmonary aspergillosis (ABPA) and sporotrichosis, but poor attainment of therapeutic drug levels is frequently observed with available oral formulations. A formulation of 'SUper BioAvailability itraconazole' (SUBA-itraconazole; Lozanoc®) has been developed, with adult studies demonstrating rapid and reliable attainment of therapeutic levels, yet paediatric data are lacking.

News & Events

First-of-its-kind findings show that newborns exclusively fed colostrum in their first 72 hours of life were five times less likely to develop a peanut allergy by 12-18 months, and 11 times less likely to develop multiple food allergies (such as egg or cow’s milk) compared with infants who also received formula

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Previous reports suggested that food proteins present in human milk (HM) may trigger symptoms in allergic children during breastfeeding, but existing evidence has never been reviewed systematically.

News & Events

As a child health researcher, I'm often asked by new Mums what's the best thing they can do for their babies? And my answer is always the same, breastfeed.

Research

These data show that fathers are prepared to use a breastfeeding-focused online forum in a variety of ways to facilitate social support