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Tertiary Lymphoid Structures (TLSs) are ectopic lymphoid aggregates that form within the tumor microenvironment (TME) and are increasingly recognized as potential prognostic biomarkers in various cancers. However, the spatial heterogeneity and prognostic value of TLSs in esophageal squamous cell carcinoma (ESCC) remain poorly defined. This study aimed to characterize the spatial distribution patterns of TLSs and tumor-infiltrating lymphocytes (TILs), and to establish a refined prognostic model for ESCC patients in both surgery-only and neoadjuvant therapy cohorts.
After randomized, controlled trials established that consumption of folic acid before pregnancy and during the early weeks of gestation reduces the risk...
Cytokines in milk like transforming growth factor-beta (TGF-beta) have been shown to induce oral tolerance in experimental animal studies
This review aims to systematically identify and summarise the effects of different antifungal therapies in children with proven, probable or suspected...
Stereotypic hand movements are a feature of Rett Syndrome but few studies have observed their nature systematically.
Antismoking mass media campaigns have been shown to reduce smoking prevalence in the mainstream community.
Growth is the rate of increase in a dimension per unit time. Mass is the dimension traditionally considered for fetal growth because it is the most easily and..
This paper discusses changes in diagnostic criteria, decreasing age at diagnosis, improved case ascertainment, diagnostic substitution, and social influences.
CD8α+ DCs are not the sole subset cross-presenting cell associated tumor antigens from a solid tumor
The contributors, all world experts in their fields, also discuss what we can learn from the presence of co-morbidities.