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Bronchiectasis Research for Improving Lung Health outcomes and Treatment (BRIGHT)This prospective, longitudinal cohort study will examine airway sputum, lung function, and clinical surveillance data of children with bronchiectasis attending Perth Children’s Hospital.
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Human Milk Sodium and Potassium as Markers of Mastitis in Mothers of Preterm InfantsThis prospective longitudinal study examined changes in milk sodium concentration (Na) and sodium:potassium ratio (Na:K), microbiological culture, milk production, and breast health in relation to mastitis after preterm birth.
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Early versus late parenteral nutrition in term and late preterm infants: study protocol for a randomised controlled trialDespite the wide use of parenteral nutrition (PN) in neonatal intensive care units (NICU), there is limited evidence regarding the optimal time to commence PN in term and late preterm infants.
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Neonatal Docosahexaenoic Acid in Preterm Infants and Intelligence at 5 YearsDocosahexaenoic acid (DHA) is a component of neural tissue. Because its accretion into the brain is greatest during the final trimester of pregnancy, infants born before 29 weeks' gestation do not receive the normal supply of DHA. The effect of this deficiency on subsequent cognitive development is not well understood.
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Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancySlightly less than 1 h of general anaesthesia in early infancy does not alter neurodevelopmental outcome at age 5 years
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Outcomes in extremely low birth weight (≤500 g) preterm infants: A Western Australian experienceExtremely preterm infant survival has significantly improved with advanced neonatal care; however outcomes of infants born with birth weight ≤500 g remain poor. We aimed to review outcomes of this cohort in our Institution.
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Increasing diversity within the Global Lung Function InitiativeThe Global Lung Function Initiative has worked to develop all‐age, multi‐ethnic reference equations for the major clinical lung function tests
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Impaired Cytokine Responses to Live Staphylococcus epidermidis in Preterm Infants Precede Gram-positive, Late-onset SepsisLate-onset sepsis (LOS) with Staphylococcus epidermidis is common in preterm infants, but the immunological mechanisms underlying heightened susceptibility are poorly understood. Our aim is to characterize the ontogeny of cytokine responses to live S. epidermidis in preterm infants with and without subsequent Gram-positive LOS.
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Prediction models for the development of COPD: A systematic reviewWe aimed to systematically review and assess the performance of all published models that predicted development of COPD
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Plasma cytokine profiles in very preterm infants with late-onset sepsisVery preterm infants have a marked innate inflammatory response at the time of late-onset sepsis
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Is forced oscillation technique the next respiratory function test of choice in childhood asthmaWhile spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are unable to perform FOM.
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Premedication with salbutamol prior to surgery does not decrease the risk of perioperative respiratory adverse events in school-aged childrenPremedication with salbutamol to children prior to their surgery did not reduce their risk of Perioperative respiratory adverse events
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An Official ATS/ERS Workshop Report: Evaluation of Respiratory Mechanics and Function in the Pediatric and Neonatal Intensive Care UnitsThis report summarizes techniques available for ventilated and spontaneously breathing infants and children in the ICU
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Composition of early life leukocyte populations in preterm infants with and without late-onset sepsisComposition of leukocyte populations in the first month of life remains incompletely characterised, particularly in preterm infants who go on to develop late-onset sepsis (LOS). The aim of the study was to characterise and compare leukocyte populations in preterm infants with and without LOS during the first month of life.
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Defining the appropriate waiting time between multiple-breath nitrogen washout measurementsThis letter addresses the recommendations by the American Thoracic Society & European Respiratory Society in 2005, that patients must wait 15-60mins between...
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Associations of Maternal Milk Feeding With Neurodevelopmental Outcomes at 7 Years of Age in Former Preterm InfantsMaternal milk feeding may have unique long-term neurodevelopmental benefits in very preterm infants. We examine the extent to which maternal milk feeding after very preterm birth is associated with cognitive, academic, and behavioral outcomes at school age.
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Effects of adopting the new global lung function initiative 2012 reference equations on the interpretation of spirometryThe aim of this study was to document the likely interpretative effects of changing from commonly used current spirometry reference equations to the GLI2012...
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Early or delayed parenteral nutrition for infants: what evidence is available?Recent studies in very premature infants (<32 weeks gestation) have shown that early commencement of parenteral nutrition immediately after birth improves physical growth. However, there are concerns that early use of very high dose of amino-acids (>3.5 g/kg/day immediately after birth) may cause metabolic acidosis, elevated blood urea, slower head growth and refeeding-hypophosphatemia syndrome. A recent multicentre randomized controlled trial found that commencement of parenteral nutrition within 24-h of admission increases the risk of infections and prolongs the duration of ventilation and ICU stay in full-term neonates, older infants and children. The study also found that delaying to day 8 of admission increased the risk of hypoglycaemia.