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Targeted Therapy for Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma of Childhood

Systemic Epstein-Barr virus-positive T-cell lymphoma of childhood (STCLC) is a rare and highly aggressive malignancy with a dismal prognosis and no standard curative treatment. This report describes the first reported case of STCLC in a White child who, after experiencing failure with intensive chemotherapy regimens, achieved a complete response following targeted immunotherapy.

Citation:
Holzmann JJ, O’sullivan M, Charles A, …….. Kotecha RS, Valvi S. Targeted Therapy for Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma of Childhood. JNCCN J Nat Compr Cancer Netw. 2026;24(6). 

Keywords:
Epstein-Barr Virus; infections; complications; diagnosis; virology;hematopoietic stem cell transplantation; lymphoma; T-cell; therapy; etiology; immunotherapy

Abstract:
Systemic Epstein-Barr virus-positive T-cell lymphoma of childhood (STCLC) is a rare and highly aggressive malignancy with a dismal prognosis and no standard curative treatment. This report describes the first reported case of STCLC in a White child who, after experiencing failure with intensive chemotherapy regimens, achieved a complete response following targeted immunotherapy.